Quaalude

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Mandrax Quaalude 300 (methaqualone) are a synthetic, barbiturate-like, central nervous system depressant. Methaqualone is an anxiolytic and a sedative-hypnotic drug. Quaaludes were introduced as a safe barbiturate substitute, but they later showed that the possibility of addiction and withdrawal symptoms were similar to those of barbiturates.
Uses of Mandrax Quaalude 300 (methaqualone)
In prescribed doses, Mandrax Quaalude 300 (methaqualone) promotes relaxation, sleepiness and sometimes a feeling of euphoria. It causes a drop in blood pressure and slows the pulse rate. These properties are the reason why it was initially thought to be a useful sedative and anxiolytic.
In 1972, Mandrax Quaalude 300 (methaqualone) were one of the most prescribed sedatives in United States.
It became a recreational drug due to its euphoric effect. Mandrax Quaalude were a popular drug of abuse during much of the 1970s, even though both the United States and Britain tightened control around their use and dispensing. “Luding out” where Quaaludes were taken with wine, became a popular college pastime.
Quaaludes Dosage
When it was a legal medicine, methaqualone was available in tablet and capsule form and came in different strengths.
Oral Mandrax Quaalude dosages was 75-150mg for light sedation. A common prescribed dose was 300mg. Up to 600mg was used for strong sedation. Tolerance develops rapidly and some users may take up to 2000mg daily to achieve the same effects.
Onset of action is approximately 30 minutes after taking Mandrax Quaalude and duration of action is between 5 to 8 hours.
Overdose
Overdose of Mandrax Quaalude 300 (methaqualone) can lead to seizures, coma or death.
Taking doses of over 300mg can be dangerous for first time users. Depending on the state of the user’s tolerance, doses of about 8,000mg per day can be fatal and others on even higher doses (of up to 20,000mg) may survive.
Death can result at much lower doses if Mandrax Quaalude are taken with alcohol, which is also a central nervous system depressant.
Mandrax Quaalude 300 (methaqualone) use during Pregnancy

Methaqualone is a sedative that falls outside the benzodiazepine and barbiturate classes. It was once a popular pharmaceutical and recreational drug, but its current use is largely relegated to Africa, particularly South Africa.

Because it faced few restrictions when it first entered the market, the drug was widely prescribed and perceived as uniquely safe. We now know methaqualone can be used recreationally and can cause physical dependence.

A lot of lore exists around the effects. In reality, it’s not a massively unique substance and it can be compared to barbiturates, ethanol, carisoprodol, and meprobamate.


Methaqualone = Quaalude; Mandrax; 2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone; Sopor; Metolquizolone; Metaqualon; Ortonal; Cateudyl; Melsomin; Melsedin; Parest

PubChem: 6292

Molecular formula:  C16H14N2O

Molecular weight: 250.301 g/mol

IUPAC: 2-methyl-3-(2-methylphenyl)quinazolin-4-one


 

Dose

Oral

Medical

  • Daytime sedation/anxiolysis: 75 mg up to 3-4x daily
  • Sleep: 150 – 400 mg

Recreational

  • Light: 150 – 300 mg
  • Common: 300 – 600 mg
  • Strong: 600+ mg

Timeline

Oral

Total (medical): 6 – 8 hours

Total (recreational): 4 – 6 hours

Onset: ~00:30

The core recreational effects persist for about 6 hours, but some sedation and impairment can last beyond that point.

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